Cholangiocarcinoma

Cholangiocarcinoma

Cholangiocarcinoma Service

Cholangiocarcinoma is a cancerous (malignant) growth in one of the ducts that carries bile from the liver to the small intestine.

Causes

Bile duct cysts

Chronic biliary irritation

History of infection with the parasitic worm, liver flukes

Primary sclerosing cholangitis

Symptoms

Chills

Clay-colored stools

Fever

Itching

Loss of appetite

Pain in the upper right abdomen that may radiate to the back

Weight loss

Yellowing of the skin (jaundice)

Exams and Tests

Tests that show a tumor or blockage in the bile duct:

Abdominal CT scan

Abdominal ultrasound

CT scan-directed biopsy

Cytology

Endoscopic retrograde cholangiopancreatography (ERCP)

Percutaneous transhepatic cholangiogram (PTCA)

Blood tests that show abnormal function:

Liver function tests (especially bilirubin)

Treatment:

The goal is to treat the cancer and the blockage it causes. When possible, surgery to remove the tumor is the treatment of choice and may result in a cure.

Chemotherapy or radiation may be given after surgery to decrease the risk of the cancer returning.

Endoscopic therapy or surgery can clear blockages in the biliary ducts and relieve jaundice in patients when the tumor cannot be removed.

For patients with cancer that cannot be removed, radiation therapy may be beneficial. Chemotherapy may be added to radiation therapy or used when the tumor has spread.

When to Contact us

If you have jaundice or other symptoms of cholangiocarcinoma.

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